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Tseng, Y.C.1, Ho, G.D.2, Chen, T.T.W.3, Huang, B.F.4, Cheng, P.C.5, Chen, J.L.6 and Peng, S.Y.7* 1Institute of Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien, Taiwan 2Effpha Pharma Management Corp. Taipei Taiwan 3Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan 4Department of laboratory medicine, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan 5Department of Parasitology and Center for International Tropical medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan 6Department of Medical Informatics, College of Medicine, Tzu Chi University, Hualien, Taiwan 7Department of Biochemistry, College of Medicine, Tzu Chi University, Hualien, Taiwan *Corresponding author email: [email protected] Received 2 May 2013; received in revised form 16 September 2013; accepted 1 October 2013